发明名称 |
METHOD FOR DETECTING HUMAN T CELL LEUKEMIA VIRUS INFECTION OR ADULT T-CELL LEUKEMIA ONSET, ITS DIAGNOSTIC AND MEDICINE FOR PREVENTING AND TREATING ADULT T-CELL LEUKEMIA |
摘要 |
PROBLEM TO BE SOLVED: To provide a method for simply judging an ATL onset in early stages, a diagnostic for an ATL onset and its therapeutic agent or prophylactic. SOLUTION: It is determined that a subject is a HTLV-1 infected patient and/or ATL patient by using reduction of expression level of NDRG2 in a subject-derived cell as an index when the expression level of NDRG2 in the subject-derived cell is compared with the expression level of NDRG2 in a control cell. Otherwise, it is determined that a subject is a HTLV-1 infected patient and/or ATL patient by using much methylation of an NDRG2 promoter in a subject-derived cell as an index when the methylation is measured. The ATL diagnostic comprises an antibody against an NDRG2 protein. The medicine for preventing and/or treating ATL comprises an NDRG2 gene or an NDRG2 protein as an active ingredient. COPYRIGHT: (C)2009,JPO&INPIT
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申请公布号 |
JP2009189271(A) |
申请公布日期 |
2009.08.27 |
申请号 |
JP20080031855 |
申请日期 |
2008.02.13 |
申请人 |
UNIV OF MIYAZAKI;MIYAZAKIKEN SANGYO SHIEN ZAIDAN |
发明人 |
MORISHITA KAZUHIRO;TANIWAKI MASAFUMI;HAMAZAKI MAKOTO |
分类号 |
C12Q1/68;A61K31/7088;A61K38/00;A61K48/00;A61P35/02;C12N15/09;G01N33/569 |
主分类号 |
C12Q1/68 |
代理机构 |
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