发明名称 |
Screening for anti-cancer compounds using netrin-1 activity |
摘要 |
The subject matter of the present invention relates to an in vitro method for the screening of anti-cancer compounds based on the capacity for these compound to interact with netrin-1 receptor and/or to inhibit the dimerization of the intracellular domain of the netrin-1 receptor expressed in tumor cells. The invention also relates to a method for predicting the presence of metastatic or aggressive cancer, or for determining the efficiency of an anti-cancer treatment based on the measuring of the expression level of netrin-1. The invention further comprises kits and compounds as a medicament for the treatment of cancer such as metastatic breast cancer, related to the overexpression of netrin-1 by the tumor cells. |
申请公布号 |
ZA200806913(B) |
申请公布日期 |
2009.08.26 |
申请号 |
ZA20080006913 |
申请日期 |
2008.08.12 |
申请人 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS);CENTRE LEON BERARD |
发明人 |
FITAMANT, JULIEN;BERNET, AGNES;MEHLEN, PATRICK |
分类号 |
G01N |
主分类号 |
G01N |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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