发明名称 |
POLYPEPTIDES WITH ENHANCED ANTI-INFLAMMATORY AND DECREASED CYTOTOXIC PROPERTIES AND RELATING METHODS |
摘要 |
<p>The invention provides a polypeptide containing at least one IgG Fc region, wherein said at least one IgG Fc region is glycosylated with at least one galactose moiety connected to a respective terminal sialic acid moiety by a a 2, 6 linkage, and wherein said polypeptide having a higher anti-inflammatory activity as compared to an unpurified antibody.</p> |
申请公布号 |
EP2091969(A2) |
申请公布日期 |
2009.08.26 |
申请号 |
EP20070812601 |
申请日期 |
2007.07.03 |
申请人 |
THE ROCKFELLER UNIVERSITY |
发明人 |
NIMMERJAHN, FALK;KANEKO, YOSHIKATSU;RAVETCH, JEFFREY V. |
分类号 |
C07K16/00;A61K39/395;C07K1/00;C12P21/08 |
主分类号 |
C07K16/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|