| 发明名称 |
GLP-1, exendin-4, peptide analogs and uses thereof |
| 摘要 |
<p>The invention relates to novel polypeptide analogues of GLP-1 and exendin-4. The polypeptide, in a preferred embodiment, is insulinotropic and long-acting. Preferably, the polypeptide's insulinotropic effect is comparable to or exceeds the effect of an equimolar amount of GLP-1 or exendin-4. The invention also relates to a method of treating a subject with diabetes, comprising administering to the subject the polypeptide of the invention in an amount that has an insulinotropic effect. The invention also relates to methods of using GLP-1, exendin-4, and polypeptide analogues thereof for neuroprotective and neurotrophic effects.</p> |
| 申请公布号 |
EP2275117(A1) |
申请公布日期 |
2011.01.19 |
| 申请号 |
EP20100177860 |
申请日期 |
2002.07.30 |
| 申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
GREIG, NIGEL H.;EGAN, JOSEPHINE;DOYLE, MAIRE;HOLLOWAY, HAROLD;PERRY, TRACY ANN |
| 分类号 |
A61K38/10;A61K38/28;A61K38/00;A61K38/16;A61K38/26;A61P3/10;A61P9/10;A61P19/08;A61P25/00;A61P25/02;A61P25/14;A61P25/16;A61P25/28;A61P43/00;C07K7/00;C07K14/00;C07K14/47;C07K14/575;C07K14/605 |
主分类号 |
A61K38/10 |
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