发明名称 |
MODIFIED SOLUBLE FGF RECEPTOR FC FUSIONS WITH IMPROVED BIOLOGICAL ACTIVITY |
摘要 |
<p>The invention relates to modified soluble FGF receptor Fc fusions comprising a fusion of a soluble fragment or domain of the FGF receptor part (targeting or binding moiety) with an Fc region of an immunoglobulin part (effector function moiety), having improved biological activity including ADCC/CDC activities, compositions containing them, and method of producing such modified soluble FGF receptor Fc fusion molecules.</p> |
申请公布号 |
EP2092069(A2) |
申请公布日期 |
2009.08.26 |
申请号 |
EP20070866627 |
申请日期 |
2007.11.28 |
申请人 |
CENTELION |
发明人 |
NESBIT, MARK;CAMERON, BEATRICE;BLANCHE, FRANCIS;SORDELLO, SYLVIE;NICOLAZZI, CELINE;TROMBE, MARC |
分类号 |
C12N15/62;A61K38/17;A61K47/48;C07K14/47;C07K14/71 |
主分类号 |
C12N15/62 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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