THIOLATED EUTRAGIT MICROSPHERE FORMULATION FOR ORAL ADMINISTRATION OF DRUG

摘要

A thiolated eutragit microsphere drug carrier for oral administration is provided to minimize the reduction of drug at low pH concentration and enhance the availability of drug. A method for manufacturing a thiolated eutragit microsphere drug carrier for oral administration comprises: a step of reacting L-cysteine hydrochloride with eutragit to obtain thiolated eutragit; a step of resolving thiolated eutragit in organic solvent to make thiolated eutragit solution; a step of resolving protein drug in distilled water to make drug solution; a step of adding protein drug solution in thiolated eutragit solution and treating with ultrasonic wave; a step of adding surfactant solution; and a step of solvent from water/oil/water emulsion and centrifuging.