发明名称 |
Specific binding sites in collagen for integrins and use thereof |
摘要 |
The present invention identified a high affinity binding sequence in collagen type III for the collagen-binding integrin I domains. Provided herein are the methods used to characterize the sequence, the peptides comprising this novel sequence and the use of the peptides in enabling cell adhesion. Also provided herein are methods to identify specific integrin inhibitors, sequences of these inhibitors and their use in inhibiting pathophysiological conditions that may arise due to integrin-collagen interaction.
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申请公布号 |
US2009203627(A1) |
申请公布日期 |
2009.08.13 |
申请号 |
US20090383746 |
申请日期 |
2009.03.26 |
申请人 |
HOOK MAGNUS;XU XUEJUN;KIM JIYEUN |
发明人 |
HOOK MAGNUS;XU XUEJUN;KIM JIYEUN |
分类号 |
A61K38/08;C07K7/06;C07K19/00;C12N5/06;C12N5/10;C12N15/63;G01N33/566 |
主分类号 |
A61K38/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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