发明名称 |
METHOD OF PRODUCING FACTOR VIII PROTEINS BY RECOMBINANT METHODS |
摘要 |
Provided herein are methods and compositions for producing Factor VIII proteins. Such methods include introducing into a cell a nucleic acid molecule encoding a Factor VIII protein operably linked to a promoter, wherein the promoter is characterized by the ability to produce commercially viable Factor VIII protein; and incubating the cell under conditions for producing commercially viable Factor VIII protein. Also provided are nucleic acid molecules which encode a Factor VIII protein operably linked to a Chinese hamster elongation factor 1-alpha (CHEF1) promoter, which may be used in the methods provided herein.
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申请公布号 |
US2009203077(A1) |
申请公布日期 |
2009.08.13 |
申请号 |
US20080252024 |
申请日期 |
2008.10.15 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN |
发明人 |
KAUFMAN RANDAL J.;PIPE STEVEN W.;GRIFFITH MICHAEL |
分类号 |
C12P21/02;C12N15/12 |
主分类号 |
C12P21/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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