发明名称 |
3,8-DIAMINOTETRAHYDROQUINOLINE DERIVATIVE |
摘要 |
<p>Disclosed is a compound which has a potent agonistic activity on GHS-R and is useful as a therapeutic agent for systemic wasting diseases including cachexia. Specifically disclosed is a 3,8-diaminotetrahydroquinoline derivative represented by general formula (1a) [wherein X represents CH2, C=O, CH-OR, CH-SR or CH-NRR'; m represents a number of 1 or 2; Ar represents a phenyl group, a naphthyl group, a 5- or 6-membered aromatic heterocyclic group having one or two atoms selected from S, N and O, or the like; R1 and R2 independently represent a hydrogen atom or a methyl group; R3 represents an alkyl group having 1 to 6 carbon atoms, or the like; n represents a number of 0 or 1; R4 and R5 independently represent a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, or the like; and R6, R7, R and R' independently represent a hydrogen atom or an alkyl group having 1 to 6 carbon atoms] or a salt thereof.</p> |
申请公布号 |
WO2009098901(A1) |
申请公布日期 |
2009.08.13 |
申请号 |
WO2009JP00487 |
申请日期 |
2009.02.06 |
申请人 |
ZERIA PHARMACEUTICAL CO., LTD.;WATANABE, TAKESHI;TERAUCHI, MASARU;NAGASAWA, MASAAKI;TANAKA, KOUICHIROU;WASHIDUKA, MASATAKA |
发明人 |
WATANABE, TAKESHI;TERAUCHI, MASARU;NAGASAWA, MASAAKI;TANAKA, KOUICHIROU;WASHIDUKA, MASATAKA |
分类号 |
C07D401/14;A61K31/4709;A61K38/00;A61P3/00;A61P9/04;A61P11/00;A61P29/00;A61P31/04;A61P43/00;C07D215/38;C07D401/04;C07D409/14;C07K5/06 |
主分类号 |
C07D401/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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