发明名称 |
METHODS AND DOSAGE FORMS FOR CONTROLLED DELIVERY OF PALIPERIDONE AND RISPERIDONE |
摘要 |
Dosage forms and methods for providing a substantially ascending rate of release of paliperidone or risperidone are provided. The sustained release dosage forms provide therapeutically effective average steady-state plasma paliperidone or risperidone concentrations when administered once per day. This once-a-day dosing regimen results in only one peak plasma paliperidone or risperidone concentration occurrence in each 24 hour period. In addition, the peak plasma paliperidone or risperidone concentration occurs at a later time following dose administration and exhibits a lesser magnitude than the peak plasma paliperidone or risperidone concentration that occurs following administration of paliperidone or risperidone in an immediate-release dosage form.
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申请公布号 |
US2009202631(A1) |
申请公布日期 |
2009.08.13 |
申请号 |
US20090428422 |
申请日期 |
2009.04.22 |
申请人 |
YAM NYOMI V;REYES IRAN;DAVAR NIPUN;AYER ATUL D;LEE JULIE;SEROFF SONYA;GUPTA SUNEEL K;SATHYAN GAYATRI |
发明人 |
YAM NYOMI V.;REYES IRAN;DAVAR NIPUN;AYER ATUL D.;LEE JULIE;SEROFF SONYA;GUPTA SUNEEL K.;SATHYAN GAYATRI |
分类号 |
A61K31/519;A61K9/20;A61K31/506 |
主分类号 |
A61K31/519 |
代理机构 |
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地址 |
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