发明名称 |
USE OF THREE-DIMENSIONAL MICROFABRICATED TISSUE ENGINEERED SYSTEMS FOR PHARMACOLOGIC APPLICATIONS |
摘要 |
A method of determining toxicity of a test agent in a tissue including A) incubating a test agent within a three-dimensional tissue engineered structure comprising a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, and wherein the first mold or polymer scaffold has microchannels comprising vessels that bifurcate, and B) obtaining information from step A) to assess toxicity. |
申请公布号 |
EP1589814(B1) |
申请公布日期 |
2009.08.12 |
申请号 |
EP20040702899 |
申请日期 |
2004.01.16 |
申请人 |
THE GENERAL HOSPITAL CORPORATION |
发明人 |
VACANTI, JOSEPH P. M. D.;RUBIN, ROBERT;CHEUNG, WING |
分类号 |
A01N1/00;C12N5/00;C12Q;C12Q1/00;C12Q1/26;C12Q1/34;C12Q1/42;C12Q1/44;C12Q1/48;G01N33/50;G01N33/53 |
主分类号 |
A01N1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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