| 发明名称 |
THERAPEUTIC HUMAN ANTI-IL-1R1 MONOCLONAL ANTIBODY |
| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide an antibody interacting with interleukin-1 receptor type 1 (IL-1R1), a method for treating IL-1-mediated diseases by administering the antibody, and a method for detecting the amount of IL-1R1 in a sample by using the antibody. <P>SOLUTION: An isolated human antibody comprising a heavy chain and a light chain, specifically binding interleukin-1 receptor type 1 (IL-1R1) or an antigen-binding or immunologically functional immunoglobulin fragment of the human antibody is provided, wherein the heavy chain comprises a heavy chain variable region comprising a specific amino acid sequence. <P>COPYRIGHT: (C)2009,JPO&INPIT |
| 申请公布号 |
JP2009173659(A) |
申请公布日期 |
2009.08.06 |
| 申请号 |
JP20090055682 |
申请日期 |
2009.03.09 |
| 申请人 |
AMGEN INC;MEDAREX INC |
发明人 |
VARNUM BRIAN;VEZINA CHRIS;WITTE ALISON;QIAN XUEMING;MARTIN FRANK;HUANG HAICHUN;ELLIOTT GARY |
| 分类号 |
C07K16/28;A61K39/395;A61P1/02;A61P1/04;A61P1/18;A61P9/00;A61P9/04;A61P9/10;A61P11/00;A61P11/06;A61P15/00;A61P17/02;A61P19/02;A61P19/10;A61P21/00;A61P25/04;A61P25/14;A61P25/16;A61P25/20;A61P25/28;A61P27/02;A61P31/04;A61P35/00;A61P35/02;A61P37/06;A61P43/00;C12N15/09;C12P21/08;G01N33/15;G01N33/50 |
主分类号 |
C07K16/28 |
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