发明名称 |
INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS |
摘要 |
<p>Provided herein are methods for identifying compounds that are inhibitors of a calcium-activated chloride channel. Aminothiophene and aminothiazole compounds, and compositions comprising these compounds, described herein that inhibit efflux of chloride through a calcium-activated chloride channel are useful for treating diseases, disorders, and sequelae of diseases, disorders, and conditions that are associated with aberrantly increased chloride and fluid secretion, for example, secretory diarrhea.</p> |
申请公布号 |
WO2009079373(A3) |
申请公布日期 |
2009.08.06 |
申请号 |
WO2008US86600 |
申请日期 |
2008.12.12 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;VERKMAN, ALAN, S.;DE LA FUENTE GONZALEZ, RICARDO |
发明人 |
VERKMAN, ALAN, S.;DE LA FUENTE GONZALEZ, RICARDO |
分类号 |
C07D333/36;C07D333/42 |
主分类号 |
C07D333/36 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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