发明名称 |
FUNCTIONAL NUCLEIC ACID LIGANDS TO FLUORESCENT PROTEINS |
摘要 |
The present invention relates to a nucleic acid aptamer having a first domain that binds to a fluorescent protein. The nucleic acid aptamer forms a molecular complex whereby the aptamer binds a fluorescent protein at the first domain. A constructed DNA molecule, expression systems, and host cells containing the molecular complex are also disclosed. The invention also relates to a system containing a first DNA molecule encoding the nucleic acid aptamer of the present invention and a second DNA molecule encoding a fluorescent protein capable of being bound by the first domain. Methods of detecting a molecular target and determining location of a molecular target using the nucleic acid aptamer of the invention are also disclosed.
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申请公布号 |
US2009197271(A1) |
申请公布日期 |
2009.08.06 |
申请号 |
US20070305102 |
申请日期 |
2007.06.18 |
申请人 |
CORNELL RESEARCH FOUNDATION, INC. |
发明人 |
KOTLIKOFF MICHAEL;SHI HUA;SHUI BO;LIS JOHN T. |
分类号 |
C12Q1/68;C07H21/04;C07K14/435;C12N5/10 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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