METHODS FOR PREDICTION OF CLINICAL OUTCOME TO EPIDERMAL GROWTH FACTOR RECEPTOR INHIBITORS BY CANCER PATIENTS

摘要

The present invention relates to a method to obtain an expression score to evaluate gene expression in a tissue specimen obtained from a person having or suspected of having cancer comprising:
a) determining by immunohistochemistry a fraction score, wherein the fraction score corresponds to the percentage of cells in the tissue specimen that stain positive for a biomarker;
b) determining an intensity score that corresponds to the staining intensity of the biomarker in the sample of tumor cells;
c) calculating an expression score that is a numerical evaluation of the product of the fraction score and the intensity score.