摘要 |
A composition which contains caffeine, its analog, or its pharmaceutically allowable salt is provided to suppress infiltration, metastasis, and proliferation and prevent and/or treat brain cancer. A composition for preventing and treating brain cancer comprises caffeine, caffeine anaolog, or its pharmaceutically allowable salt as an active ingredient. The caffeine, caffeine analog or its pharmaceutically allowable salt has the content of 0.3-30 mM. The daily dose of the composition is 1-5 mg/kg and the composition is administered at one time or several times. The brain cancer is glioma, exothelioma, pituitary adenoma, schwannoma, craniopharyngioma or the congenital brain tumor. The composition selectively block the subtype 3 of activation of inositol-1,4,5-triphosphate receptoer(IP3R).
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申请人 |
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY |
发明人 |
LEE CHANGJOON JUSTIN;ROH, EUN JOO;CHOI, JIN KYU;HAN, KYUNG SUK;PARK, JUNG EUN;KANG, SANG SOO |