| 摘要 |
The present invention relates to the compound of formula (I):
in which
R 1 represents a hydrogen atom, an optionally labelled halogen atom, a radionuclide or a Sn[(C 1 -C 4 )alkyl] 3 group,
Ar represents an aryl group or a heteroaryl group,
R 9 represents a hydrogen atom, a (C 1 -C 4 )alkyl group or forms together with the group R 1 -Ar a ring fused with the Ar group,
A represents a group of formula (²) or (´):
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ -(CH 2 ) t -€ƒ€ƒ€ƒ€ƒ€ƒ(²)
R 3 and R 4 independently represent a hydrogen atom, a (C 1 -C 6 )alkyl group, a (C 1 -C 6 )alkenyl group or a group of formula (y):
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ -Y-Z-W-R 11 €ƒ€ƒ€ƒ€ƒ€ƒ(³)
wherein R 11 represents an optionally labelled halogen atom, a radionuclide, an aryl or heteroaryl group optionally substituted by an optionally labelled halogen atom, a radionuclide, a -NO 2 group, a -NR 5 R 6 group, a -N + R 5 R 6 R 7 X - group, or a -OSO 2 R 12 group, and their addition salts with pharmaceutically acceptable acids. The present invention also relates to pharmaceutical compositions comprising them and to their use in diagnosis, in particular with SPECT, PET and in therapy. |
