发明名称 |
RNAI MODULATION OF SCAP AND THERAPEUTIC USES THEREOF |
摘要 |
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a SCAP gene (Human SCAP gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of a SCAP gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by Human SCAP expression and the expression of a SCAP gene using the pharmaceutical composition; and methods for inhibiting the expression of a SCAP gene in a cell. ® KIPO & WIPO 2009 |
申请公布号 |
KR20090083338(A) |
申请公布日期 |
2009.08.03 |
申请号 |
KR20097007581 |
申请日期 |
2007.09.18 |
申请人 |
ALNYLAM PHARMACEUTICALS, INC.;BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
SOUTSCHEK JUERGEN;TAN PAMELA;HORTON JAY D.;BROWN MICHAEL S.;GOLDSTEIN JOSEPH L.;MOON, YOUNG AH |
分类号 |
A61K48/00;C07H21/02;C12N15/113 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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