发明名称 ANGIOTENSIN II RECEPTOR ANTAGONISTS
摘要 A compound having the structure (I) wherein R is an angiotensin receptor antagonist active group, Y is selected from the group consisting of (II), and 2) -C(R1H)OC(O)X((CR12R13)-(CHR10)m-(CH2)n-Zp-(CH2)q-(CHR11)r-(CR16R17))-R5; Z is O- or (CR14R15)-; m, n, p, q, and r are independently selected from the group consisting of 0 and 1; X is O- or (CR18R19)-; R1 is selected from the group consisting of hydrogen, C1-4 alkyl, aryl and C1-4 alkylaryl; R5 is -O-N=N(O)-NR3R4; or a pharmaceutically acceptable salt or hydrate thereof, which is useful for treating hypertension.
申请公布号 CA2711134(A1) 申请公布日期 2009.07.30
申请号 CA20092711134 申请日期 2009.01.08
申请人 MERCK SHARP & DOHME CORP. 发明人 ALI, AMJAD;FRANKLIN, CHRISTOPHER;LO, MICHAEL MAN-CHU;WHITEHEAD, BRENT R.
分类号 A01N43/64;A61K31/41;C07D257/00 主分类号 A01N43/64
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