发明名称 |
HYDROPHOBIC MODIFIED PRES-DERIVED PEPTIDES OF HEPATITIS B VIRUS (HBV) AND THEIR USE AS HBV AND HDV ENTRY INHIBITORS |
摘要 |
The present invention relates to hydrophobic modified preS-derived peptides of hepatitis B virus (HBV) which are derived from a HBV preS consensus sequence and are N-terminal preferably acylated and optional C-terminal modified. These hydrophobic modified preS- derived peptides of HBV are very effective HBV entry inhibitors as well as HDV entry inhibitors and are, thus, suitable for the inhibition of HBV and/or HDV infection, prevention of primary HBV and/or HDV infection as well as treatment of (chronic) hepatitis B and/or D. The present invention further relates to pharmaceutical and vaccine compositions comprising these hydrophobic modified preS-derived peptides of HBV. |
申请公布号 |
WO2009092611(A1) |
申请公布日期 |
2009.07.30 |
申请号 |
WO2009EP00476 |
申请日期 |
2009.01.26 |
申请人 |
UNIVERSITAETSKLINIKUM HEIDELBERG;MIER, WALTER;URBAN, STEPHAN |
发明人 |
MIER, WALTER;URBAN, STEPHAN |
分类号 |
C07K14/02;A61K38/16;A61K39/29 |
主分类号 |
C07K14/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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