| 摘要 |
Provided are therapeutic polypeptides such as antibodies with reduced glycosylation and methods of designing and synthesizing the same. The therapeutic polypeptides can have reduced effector functions, and also can have additional advantages including, but not limited to, more efficient expression, purification, and improved patient response. In some embodiments, the polypeptide is a recombinantly- produced humanized antibody targeting a cytokine with specificity for a particular cytokine relative to other naturally-occurring human antigens, wherein the antibody has a constant region, and wherein the constant region is aglycosylated. |
