发明名称 |
Multitargeting Interfering RNAs Having Two Active Strands And Methods For Their Design And Use |
摘要 |
Interfering RNA molecules are now designed and produced with specificity for multiple binding sequences present in distinct genetic contexts in one or more pre-selected target RNA molecules and are used to modulate expression of the target sequences. The multitargeting interfering RNA molecules have two strands that target multiple target sites on one or more pre-selected RNA molecules. Such a multitargeting interfering RNA approach provides a powerful tool for gene regulation.
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申请公布号 |
US2009192103(A1) |
申请公布日期 |
2009.07.30 |
申请号 |
US20080124629 |
申请日期 |
2008.05.21 |
申请人 |
JOHNSON & JOHNSON RESEARCH PTY. LIMITED |
发明人 |
RIVORY LAURENT PIERRE;POIDINGER MICHAEL;BIRKETT DONALD JOHN;ARNDT GREGORY MARTIN;PASSIOURA TOBY |
分类号 |
A61K31/7088;C07H21/02;C12N15/00;C12N15/63;C12P19/34 |
主分类号 |
A61K31/7088 |
代理机构 |
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代理人 |
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地址 |
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