MANIPULATION OF OXIDATIVE PHOSPHORYLATION FOR HYPERSENSITIZING TUMOR CELLS TO GLYCOLYTIC INHIBITORS

摘要

A class of glycolytic inhibitors is useful in the treatment of solid tumors by attacking anaerobic cells at the center on the tumor. 2-deoxyglucose, oxamat e and various analogs thereof are identified as having a natural selective toxicity toward anaerobic cells, and will significantly increase the efficac y of standard cancer chemotherapeutic and radiation regiments as well as new protocols emerging with anti-angiogenic agents.