HUMANIZED ANTI-A9 INTEGRIN ANTIBODIES AND THE USES THEREOF

摘要

The present invention provides humanized antibodies that immunospecifically recognize human a9 integrin. Some of these antibodies inhibit the biological functions of the a9 integrin, thereby exhibiting therapeutic effects on various disorders or diseases that are associated with a9 integrin, including cancer, e.g., the growth and metastasis of a cancer cell, and inflammatory diseases, e.g., rheumatoid arthritis, osteoarthritis, hepatitis, bronchial asthma, fibrosis, diabetes, arteriosclerosis, multiple sclerosis, granuloma, an inflammatory bowel disease (ulcerative colitis and Crohn's disease), an autoimmune disease, and so forth.