A MYELOMA CELL LINE USEFUL FOR MANUFACTURING RECOMBINANT PROTEINS IN CHEMICALLY DEFINED MEDIA

摘要

The present invention provides a novel myeloma cell line, designated C463A, and derivatives of C463A, which have the ability to grow continuously in chemically defined media. The present invention also relates to the production of proteins in cell line C463A and any cell line derived therefrom. The present invention further relates to methods for identifying cell lines capable of growing in chemically defined media. The present invention also relates to business methods where customers are provided with the cells, cell lines, and cell cultures of the present invention.