发明名称 |
Mótefni fyrir ED-B-hneppi fibrónektÃns, samsetningar, sem innihalda þau, og notkun þeirra til þess að sjúkdómsgreina og til þess að meðhöndla æxli og sjúkdóma, sem tengjast æðanýmyndun |
摘要 |
The present invention relates to antibodies with sub-nanomolar affinity specific for a characteristic epitope of the ED-B domain of fibronectin, a marker of angiogenesis Furthermore, it relates to the use of radiolabeled high affinity anti ED-B antibodies for detecting new-forming blood vessels in vivo and a diagnostic kit comprising comprising said antibody. Furthermore, it relates to conjugates comprising said antibodies and a suitable photoactive molecules (e.g. a judiciously chosen photosensitizer), and their use for the selective light-mediated occlusion of new blood vessels.
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申请公布号 |
IS2522(B) |
申请公布日期 |
2009.07.15 |
申请号 |
IS20000005708 |
申请日期 |
2000.11.10 |
申请人 |
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH |
发明人 |
DARIO NERI;FRANCESCA VITI;LORENZO TARLI;MANFRED BIRCHLER |
分类号 |
C07K16/00;C12N15/09;A61K38/00;A61K39/395;A61K41/00;A61K47/48;A61K49/00;A61K51/10;A61P35/00;C07K16/18 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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地址 |
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