发明名称 |
SOLID AND CRYSTALLINE DUTASTERIDE AND PROCESSES FOR PREPARATION THEREOF |
摘要 |
The present invention relates to a synthetic process for manufacturing Dutasteride comprising the mixed anhydride formation, subsequent reaction with 2,5- bis(trifluoromethyl)phenylamine in the presence of an appropriate Lewis catalyst and its isolation, purification and crystallization from acetonitrile/water. The invention also relates to a novel polymorphic form of Dutasteride, called form III, and a pharmaceutical composition comprising it.
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申请公布号 |
CA2709971(A1) |
申请公布日期 |
2009.07.09 |
申请号 |
CA20082709971 |
申请日期 |
2008.12.30 |
申请人 |
GADOR S.A. |
发明人 |
VECCHIOLI, ADRIANA;TOMBARI, DORA GRACIELA;MAGNONE, COSTANZA PIA;GARCIA, MARIA BEATRIZ;LABRIOLA, RAFAEL ALBERTO |
分类号 |
C07J73/00 |
主分类号 |
C07J73/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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