| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a method for constructing, applying, and producing new polypeptides in which binding activity or specificity for a hapten and an antigen is enhanced or improved. <P>SOLUTION: Target-binding polypeptides have (a) an SCR (stable core polypeptide region), and (b) at least one TBR (target-binding region). The TBR is covalently attached to the SCR and which has optionally been subjected to a maturation step in order to modify the specificity, the affinity or the activity of binding to the target. The polypeptides may self-associate to form stable dimers, aggregates, or arrays. The polypeptides have utility in the diagnostic, therapeutic, predictive, or preventative fields of the pharmaceutical and health care industries, as well as more general applications in the detection and assay of chemical substances. <P>COPYRIGHT: (C)2009,JPO&INPIT |
