发明名称 |
Highly safe intranasally administrable gene vaccines for treating alzheimer's disease |
摘要 |
An objective of the present invention is to provide a safe and effective vaccine therapy for Alzheimer's disease. A minus strand RNA viral vector carrying amyloid gene was constructed, and administered intranasally to 24- to 25-months-old APP transgenic mice. The level of serum anti-A 42 antibody was determined and showed to be markedly higher than the control. The results of histological investigation showed that the administration of a vector of the present invention markedly reduced senile plaques in all of the frontal lobe, parietal lobe, and hippocampus. The brain A level was also markedly reduced. Furthermore, the administration of a vector of the present invention did not result in lymphocyte infiltration in the central nervous system.
|
申请公布号 |
US2009170798(A1) |
申请公布日期 |
2009.07.02 |
申请号 |
US20060918862 |
申请日期 |
2006.04.20 |
申请人 |
JAPAN AS REPRESENTED BY PRESIDENT OF NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY;DNAVEC CORPORATION |
发明人 |
HARA HIDEO;TABIRA TAKESHI;YONEMITSU YOSHIKAZU;INOUE MAKOTO;TOKUSUMI YUMIKO;HASEGAWA MAMORU |
分类号 |
A61K31/7105;A61P25/28;C12N15/74 |
主分类号 |
A61K31/7105 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|