| 摘要 |
Compounds and compositions of Formula I are described, useful as anti-proliferative agents, and in particular anti-HPV, wherein: Y1A and Y1B are independently Y1; RX1 and RX2 are independently RX; Y1 is -O, -O(RX), -S, -N(RX), -N(O)(RX), -N(ORX), -N(O)(ORX), or -N(N(RX) (RX)); RX is independently R1, R2, R4, W3, or a protecting group; R1 is independently -H or alkyl of 1 to 18 carbon atoms; R2 is independently R3 or R4 wherein each R4 is independently substituted with 0 to 3 R3 groups or taken together at a carbon atom, two R2 groups form a ring of 3 to 8 carbons and the ring may be substituted with 0 to 3 R3 groups; R3 is R3a, R3b, R3c or R3d, provided that when R3 is bound to a heteroatom, then R3 is R3c or R3d; R3a is -H, -F, -Cl, -Br, -I, -CF3, -CN, N3, -NO2, or -OR4; R3b is -O, -O(R4), -S, -N(R4), -N(O)(R4), -N(OR4), -N(O)(OR4), or -N(N(R4) (R4)); R3c is -R4, -N(R4)(R4), -SR4, -S(O)R4, -S(O)2R4, -S(O)(OR4), -S(O)2(OR4), -OC(R3b)R4, -OC(R3b)OR4, -OC(R3b)(N(R4)(R4)), -SC(R3b)R4, -SC(R3b)OR4, SC(R3b)(N(R4)(R4)), -N(R4)C(R3b)R4, -N(R4)C(R3b)OR4, N(R4)C(R3b)(N(R4)(R4)), W3 or -R5W3; R3d is -C(R3b)R4, -C(R3b)OR4, -C(R3b)W3, -C(R3b)OW3 or -C(R3b)(N(R4)(R4)); R4 is -H, or an alkyl of 1 to 18 carbon atoms, alkenyl of 2 to 18 carbon atoms, or alkynyl of 2 to 18 carbon atoms; R5 is alkylene of 1 to 18 carbon atoms, alkenylene of 2 to 18 carbon atoms, or alkynylene of 2 to 18 carbon atoms; W3 is W4 or W5; W4 is R6, -C(R3b)R6, -C(R3b)W5, -SOM2R6, or -SOM2W5, wherein R6 is R4 wherein each R4 is substituted with 0 to 3 R3 groups; W5 is carbocycle or heterocycle wherein W5 is independently substituted with 0 to 3 R2 groups; and M2 is 0, 1 or 2; and pharmaceutically acceptable salts thereof.
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