发明名称 THIOGLUCOSE SPIROKETAL DERIVATIVE AND USE THEREOF AS THERAPEUTIC AGENT FOR DIABETES
摘要 <p>The present invention provides a compound represented by Formula (II): wherein R 1 , R 2 , R 3 , and R 4 are each independently selected from a hydrogen atom, an optionally substituted C 1 -C 6 alkyl group, an optionally substituted C 7 -C 14 aralkyl group and - C(=O)Rx; Rx is an optionally substituted C 1 -C 6 alkyl group, an optionally substituted aryl group, an optionally substituted heteroaryl group, an optionally substituted C 1 -C 6 alkoxy group or -NReRf; Ar 1 is an optionally substituted aromatic carbocyclic ring, or an optionally substituted aromatic heterocyclic ring which may form a condensed ring; Q is - (CH 2 ) m -(L) p - or -(L) p -(CH 2 ) m -; m is an integer selected from 0 to 2, n is an integer selected from 1 and 2, and p is an integer selected from 0 and 1; L is -O-, -S- or -NR 5 -; A is an optionally substituted aryl group or an optionally substituted heteroaryl group; and a prodrug thereof and a pharmaceutically acceptable salt thereof, and a pharmaceutical agent or a pharmaceutical composition, which comprises the compound.</p>
申请公布号 EP2072522(A1) 申请公布日期 2009.06.24
申请号 EP20070829669 申请日期 2007.10.12
申请人 CHUGAI SEIYAKU KABUSHIKI KAISHA 发明人 SATO, TSUTOMU
分类号 A61K31/7048;C07H7/06;A61P3/04;A61P3/06;A61P3/10;A61P9/04;A61P9/10;A61P9/12;A61P13/12;A61P19/06;A61P25/00;A61P27/02;A61P31/04;A61P43/00 主分类号 A61K31/7048
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