发明名称 |
FOAMABLE COMPOSITIONS AND KITS COMPRISING ONE OR MORE OF A CHANNEL AGENT, A CHOLINERGIC AGENT, A NITRIC OXIDE DONOR, AND RELATED AGENTS AND THEIR USES |
摘要 |
The present invention relates to a foamable therapeutic composition comprising: (a) a therapeutically effective concentration of at least one active agent selected from the group consisting of a channel agent, a cholinergic agent, and a nitric oxide donor; and (b) a foamable carrier comprising: i. about 50% to about 98% of a solvent selected from the group consisting of water; a hydrophilic solvent; a hydrophobic solvent; a potent solvent; a polar solvent, a silicone, an emollient, and mixtures thereof; ii. 0% to about 48% of a secondary solvent selected from the group consisting of water; a hydrophilic solvent; a hydrophobic solvent; a potent solvent; a polar solvent, a silicone, an emollient, a co-solvent, a penetration enhancer and mixtures thereof; iii. a surface-active agent; iv. about 0% to about 5% by weight of at least one polymeric agent; and v. a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition; wherein the composition is housed in a container and is substantially flowable, and which upon release expands to form a breakable foam; and wherein the foamable carrier is selected to generate a foam of good to excellent quality. The invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject, comprising administering such a composition to an afflicted target site. |
申请公布号 |
WO2008110872(A3) |
申请公布日期 |
2009.06.25 |
申请号 |
WO2007IB04522 |
申请日期 |
2007.06.22 |
申请人 |
FOAMIX LTD.;TAMARKIN, DOV;EINI, MEIR;FRIEDMAN, DORON;BERMAN, TAL;BESONOV, ALEX |
发明人 |
TAMARKIN, DOV;EINI, MEIR;FRIEDMAN, DORON;BERMAN, TAL;BESONOV, ALEX |
分类号 |
A61K9/00;A61K9/12;A61K31/44;A61K31/506;A61K31/55 |
主分类号 |
A61K9/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|