| 摘要 |
The present invention relates to new octahedral metal (III) polypyridyl complexes of general formula I
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ Me(hal) 3 (sol)(pp)€ƒ€ƒ€ƒ€ƒ€ƒ(I)
where
Me
represents rhodium or iridium
hal
is a halogenide selected from the group consisting of chlorine, bromine, fluorine and iodine or a pseudohalogenide selected from the group consisting of SCN, NCO or N 3 ,
sol
is a solvent selected from the group consisting of DMSO, H 2 O, CH 3 OH, DMF and CH 3 CN
and
pp
is a polypyridyl ligand selected from the group constisting of 2,2'-bipyridine (bpy), 1,10-phenanthroline (phen), dipyrido[3,2-f:2',3'-h]quinoxaline (dpq), dipyrido[3,2-a:2',3'-c]phenazine (dppz) and benzo[i]dipyrido[3,2-a:2',3'-c]phenazine (dppn), optionally substituted with one or more of the substituents selected from the group constisting of hydroxy, -COOR, -SO 3 H, -CHO, -CH 3 , -CF 3 , -OCH 3 , -OC 2 H 5 , -NO 2 , -CN, -NH 2 , phenyl and halogenide, wherein R = H, -CH 3 or -C 2 H 5 ,
and their use in prevention and treatment of cancer.
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