Interleukin-1 and tumor necrosis factor-a modulator; synthesis of such modulators and methods of using such modulators
摘要
Compounds are disclosed that have the chemical structure of Formula (II), (IIA) and (IIB) and their prodrug esters and acid-addition salts, and that are useful as Interleukin-1 and Tumor Necrosis Factor-a modulators, and thus are useful in the treatment of various diseases, wherein the R groups are defined in the claims.
申请公布号
ZA200801500(B)
申请公布日期
2009.06.24
申请号
ZA20080001500
申请日期
2008.02.14
申请人
NEREUS PHARMACEUTICALS, INC.;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人
THEODORAKIS, EMMANUEL, A.;MACHERLA, VENKAT, RAMI, REDDY;CHAO, TA-HSIANG;SUH, YOUNG-GER;PALLADINO, MICHAEL, A.