Grapefruit-juice-based beverage preparation method for the elimination of drug absorption interaction

摘要

A method is provided for producing a grapefruit-juice-based beverage that does not contain compounds in sufficient quantity to inhibit the intestinal CYP3A4 enzyme in vivo. The method includes the steps of clarifying grapefruit juice and treating the resulting clear serum with an absorption resin to remove soluble coumarins and furanocoumarins.