发明名称 |
A PHARMACEUTICAL FORMULATION CONTAINING GROWTH HORMONE, AN AMINO ACID AND A NON-IONIC DETERGENT |
摘要 |
The invention relates to pharmaceutical formulations comprising growth hormone, an amino acid selected from the group of Asp, Ile, Val, Leu or His, or a derivative of histidine, or a peptide comprising at least one basic amino acid and at least one acidic amino acid, and a non-ionic detergent, e.g. polysorbate or poloxamer. The formulation is stabilized against deamidation and aggregation. The formulation may be an aqueous formulation. The growth hormone may be human growth hormon e. |
申请公布号 |
CA2252535(C) |
申请公布日期 |
2009.06.23 |
申请号 |
CA19972252535 |
申请日期 |
1997.04.24 |
申请人 |
NOVO NORDISK A/S |
发明人 |
BJORN, SOREN;SORENSEN, HANS HOLMEGAARD;HANSEN, BIRTHE LYKKEGAARD;EBBEHOJ, KIRSTEN;LARSEN, SILKE MOLLER;LANGBALLE, PETER |
分类号 |
A61K38/27;A61K9/08;A61K31/00;A61K38/00;A61K47/10;A61K47/18;A61K47/22;A61K47/26;A61K47/34;A61P1/00;A61P5/00;A61P5/06;A61P15/00;A61P17/00;A61P17/02;A61P19/00;A61P19/02;A61P19/10;A61P21/00;A61P21/04 |
主分类号 |
A61K38/27 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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