| 摘要 |
Assessing the metabolic stability of novel pharmacologically active substances is at the center of drug-discovery processes. Accordingly, systems able to provide straightforward modeling of in vivo hepatic clearance are of particular interest. The present invention serves as an innovative and efficient high-throughput system for the screening of drugs. It allows to perform controlled multiple in situ (in the reaction mixture) reactions of screened compounds in terms of their stability and to determine in vivo hepatic clearance. The determinations are based on electrochemical parameters of tested compounds and do not require any biological material. The invented system has a screening rate and capacity that are several orders of magnitude higher than any currently available techniques. This invention includes a multi reaction chamber plate connected to a multifunctional apparatus for the analysis and the control of the elapsing reactions. Targeted analysis of the transformations of the screened compounds is obtained.
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