NOVEL PROCESSES FOR PREPARING SERTRALINE HYDROCHLORIDE CRYSTALLINE FORMS

摘要

The present invention discloses novel and improved processes for preparationof sertraline hydrochloride crystalline form II. Thus, for example, sertraline freebase is dissolved in isoamyl alcohol at 25 - 30 °C, pH of the mass is adjusted to 2.0 with cone, hydrochloric acid (36%) at 25 - 30 °C and then stirred for 14 hoursat 25- 30 °C. Filtered the solid and dried at 65 °C for 4 hours to give sertraline hydrochloride crystalline form II. The present invention also provides a novel process for preparation of sertraline hydrochloride crystalline form I.