发明名称 |
Fusion proteins containing recombinant cytotoxic RNAses |
摘要 |
Recombinant immunotoxins containing a cytotoxic RNAse fused to an antibody or antibody fragment may be produced in mammalian cell culture. Surprisingly, immunotoxins containing a cytotoxic RNAse fused to the N-terminus of one antibody variable domain can be prepared and retain the ability to specifically bind antigen. The immunotoxins may be used in a variety of therapeutic methods for treating diseases or syndromes associated with unwanted or inappropriate cell proliferation or activation.
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申请公布号 |
US7544487(B2) |
申请公布日期 |
2009.06.09 |
申请号 |
US20050056182 |
申请日期 |
2005.02.14 |
申请人 |
IMMUNOMEDICS, INC. |
发明人 |
GOLDENBERG DAVID M.;HANSEN HANS J.;CHANG CHIEN-HSING KEN;VANAMA SAILAJA S.;ROSSI EDMUND A. |
分类号 |
C12P21/02;A61K39/395;A61K47/48;A61K51/08;A61K51/10;C07K19/00;C12N5/06;C12N9/22;C12N15/09;C12N15/13;C12N15/63;C12P21/00 |
主分类号 |
C12P21/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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