发明名称 |
Method for the preparation of 1-benzotriazolyl carbonate esters of poly(ethylene glycol) |
摘要 |
The invention provides a method for preparing a 1-benzotriazolylcarbonate ester of a water-soluble and non-peptidic polymer by reacting a terminal hydroxyl group of a water-soluble and non-peptidic polymer with di(1-benzotriazolyl)carbonate in the presence of an amine base and an organic solvent. The polymer backbone can be poly(ethylene glycol). The 1-benzotriazolylcarbonate ester can then be reacted directly with a biologically active agent to form a biologically active polymer conjugate or reacted with an amino acid, such as lysine, to form an amino acid derivative. |
申请公布号 |
US7544738(B2) |
申请公布日期 |
2009.06.09 |
申请号 |
US20080150136 |
申请日期 |
2008.04.25 |
申请人 |
NEKTAR THERAPEUTICS AL, CORPORATION |
发明人 |
KOZLOWSKI ANTONI |
分类号 |
C08F16/06;C12N9/96;A61K47/48;C07D249/08;C08F8/30;C08F116/06;C08G65/325 |
主分类号 |
C08F16/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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