ADJUVANT FOR INFLUENZA VACCINE, AND INFLUENZA VACCINE
摘要
<p>Disclosed is an influenza vaccine containing, as an adjuvant, a novel immunostimulating oligonucleotide having an enhanced interferon (IFN)-inducing activity and a reduced inflammatory cytokine-inducing activity. Also disclosed is an adjuvant for an influenza vaccine, which comprises an oligonucleotide that is represented by the formula: 5'-(G)MPXCGYQ(G)N-3' [wherein C represents a cytosine residue; G represents a guanine residue; X and Y independently represent a nucleotide sequence that has a length of 0 to 10 nucleotides and does not contain contiguous four or more guanine residues (provided that the total length of X and Y is 6 to 20 nucleotides); XCGY represents a nucleotide sequence that has a length of 8 to 22 nucleotides and contains a palindrome sequence having a length of at least 8 nucleotides; P and Q independently represent a nucleotide residue other than a guanine residue; M represents an integer of 6 to 10; and N represents an integer of 0 to 3], and that has the total length of 16 to 37 nucleotides (provide that an oligonucleotide comprising the nucleotide sequence depicted in SEQ ID NO:5 in the Sequence Listing is excluded).</p>
申请公布号
WO2009069447(A1)
申请公布日期
2009.06.04
申请号
WO2008JP70281
申请日期
2008.11.07
申请人
TORAY INDUSTRIES, INC.;JURIDICAL FOUNDATION THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE;IWAMURA, TOMOKATSU;NOZAKI, CHIKATERU;KAMINAKA, KAZUYOSHI;MATSUDA, JUNICHI