SEH AND 11 ß-HSD1 INHIBITORS AND THEIR USE

摘要

The invention is directed to novel sEH and 11 ß-HSD1 inhibitors and their use in the treatment of diseases mediated by the sEH enzyme or the 1 1 ß-HSD1 enzyme. Specifically, the invention is directed to compounds according to Formula I: wherein A, W, and n are defined below, and to pharmaceutically-acceptable salts thereof. The compounds of the invention are sEH and 11 ß-HSD1 inhibitors and can be used in the treatment of diseases mediated by the sEH enzyme or the 11 ß-HSD1 enzyme, such as hypertension. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting sEH or the 11 ß-HSD1 and treatment of conditions associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.