Humanized anti-Aß antibodies derived from a murine antibody directed to a N-terminal epitope of Aß are described. The humanized antibodies have reduced or no human T cell epitopes and bind Aß with an affinity similar to that of the murine antibody.
申请公布号
WO2009070648(A2)
申请公布日期
2009.06.04
申请号
WO2008US84805
申请日期
2008.11.26
申请人
MEDTRONIC, INC.;SHAFER, LISA LYNN;CARR, FRANCIS JOSESPH;GREGSON, JAMES PETER;BEMBRIDGE, DAWN ANN;JONES, TIM
发明人
SHAFER, LISA LYNN;CARR, FRANCIS JOSESPH;GREGSON, JAMES PETER;BEMBRIDGE, DAWN ANN;JONES, TIM