发明名称 |
FAM26C POLYMORPHISMS AND USE THEREOF FOR THE DIAGNOSTIC AND TREATMENT OF LATE ONSET ALZHEIMER'S DISEASE |
摘要 |
Provided are methods of determining the likelihood that a subject will be diagnosed with Alzheimer's disease. Also provided are isolated and purified mammalian CALHM I, CALHM2, and CALHM3 proteins, vectors comprising a nucleic acid sequence encoding the CALHM 1, CALHM2, and CALHM3 proteins, and mammalian cells transfected with the vectors. Additionally, methods of affecting Ca2+ levels in a mammalian cell are provided. Further provided are methods of screening a test compound for the ability to alter calcium homeostasis in mammalian cells. Also, methods of affecting Ca2+ levels in mammalian cells are provided. Additionally provided are methods of screen ing a test compound for the ability to inhibit ERK I/2 phosphorylation in a mammalian cell. Further provided are methods of screening a test compound for the ability to inhibit amyloid-beta peptide accumulation in a mammalian cell or biological fluid. Also provided are methods of screening for a test compound that may affect Alzheimer's disease.
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申请公布号 |
WO2009023145(A3) |
申请公布日期 |
2009.05.22 |
申请号 |
WO2008US09556 |
申请日期 |
2008.08.08 |
申请人 |
THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH;CORNELL RESEARCH FOUNDATION, INC.;MARAMBAUD, PHILIPPE;CAMPAGNE, FABIEN |
发明人 |
MARAMBAUD, PHILIPPE;CAMPAGNE, FABIEN |
分类号 |
C12Q1/68;C12P19/34 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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