发明名称 |
HUMAN MICRORNAS AND METHODS FOR INHIBITING SAME |
摘要 |
The invention relates to isolated DNA or RNA molecules comprising at least ten contiguous bases having a sequence in a microRNA shown in SEQ ID NOs: 1-94; 281-374; 467- 481 ; 497-522; or 549, except that up to thirty percent of the bases may be wobble bases, and up to 10% of the contiguous bases may be non-complementary. The invention further relates to modified single stranded microRNA molecules, isolated single stranded anti-microRNA molecules and isolated microRNP molecules. In another embodiment, the invention relates to a method for inhibiting microRNP activity in a cell. |
申请公布号 |
WO2006119266(A3) |
申请公布日期 |
2009.05.22 |
申请号 |
WO2006US16767 |
申请日期 |
2006.05.01 |
申请人 |
ROCKEFELLER UNIVERSITY;TUSCHL, THOMAS;LANDGRAF, PABLO |
发明人 |
TUSCHL, THOMAS;LANDGRAF, PABLO |
分类号 |
C07H21/02;A61K48/00;C07H21/04;C12N15/113 |
主分类号 |
C07H21/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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