PLEUROMUTILIN DERIVATIVE HAVING ANTIBACTERIAL ACTIVITY

摘要

PROBLEM TO BE SOLVED: To provide mutilins having the principal ring structure of naturally occurring pleuromutilins which have improved antimicrobial activity, e.g. antibacterial activity. SOLUTION: The present invention provides a compound selected from 14-O-[(cycloalkyl-sulfanyl)acetyl]mutilins; 14-O-[(cycloalkyl-alkyl-sulfanyl)acetyl] mutilins; 14-O-[(cycloalkoxy)acetyl] mutilins; or 14-O-[(cycloalkyl-alkoxy)acetyl] mutilins and its use as a pharmaceutical. COPYRIGHT: (C)2009,JPO&INPIT