PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE AMINOPHOSPHINYLBUTANOIC ACID

摘要

The present invention is a process for producing optically active aminophosphinylbutanoic acids represented by the formula (2)
(in the formula (2), R 1 represents an alkyl group having 1 to 4 carbon atom(s), R 2 represents hydrogen atom or an alkyl group having 1 to 4 carbon atom(s), R 3 represents an alkyl group having 1 to 4 carbon atom(s), an alkoxy group having 1 to 4 carbon atom(s), an aryl group, an aryloxy group, or a benzyloxy group, and R 4 represents hydrogen atom or an alkyl group having 1 to 4 carbon atom(s); and * represents an asymmetric carbon atom), wherein a compound represented by the formula (1)
(in the formula (1), R 1 represents an alkyl group having 1 to 4 carbon atom(s), R 2 represents hydrogen atom or an alkyl group having 1 to 4 carbon atom(s), R 3 represents an alkyl group having 1 to 4 carbon atom(s), an alkoxy group having 1 to 4 carbon atom(s), an aryl group, an aryloxy group, or a benzyloxy group, and R 4 represents hydrogen atom or an alkyl group having 1 to 4 carbon atom(s))
is asymmetrically hydrogenated in the presence of a ruthenium-optically active phosphine complex. With the process for the production, a compound useful in a herbicide such as L-AHPB can be produced with good efficiency and high asymmetric yield.