发明名称 |
PROTEASE-RESISTANT FORMS OF VEGF-D, METHOD OF MAKING AND METHOD OF USE |
摘要 |
The present invention provides modified VEGF-D polypeptide variants that are resistant to serine protease processing and methods of making and using the same, as well pharmaceutical compositions comprising the peptide or a polynucleotide encoding the same. The VEGF-D variants comprise a VEGF homology domain, and at least one of (1) a C-terminal propeptide that is not cleavable by a serine protease, and (2) an N-terminal propeptide that is not cleavable by a serine protease. The VEGF-D variants can be made using site- directed mutagenesis. The VEGF-D variants are useful for the treatment of diseases such as cardiovascular disease and primary and secondary lymphedema, and for the prevention of stenosis and restenosis of blood vessels. |
申请公布号 |
WO2007038056(A3) |
申请公布日期 |
2009.05.14 |
申请号 |
WO2006US36357 |
申请日期 |
2006.09.19 |
申请人 |
VEGENICS LIMITED;PAAVONEN, KARRI;STACKER, STEVEN;ACHEN, MARC |
发明人 |
PAAVONEN, KARRI;STACKER, STEVEN;ACHEN, MARC |
分类号 |
C12N1/13;A61K38/18;C07K14/435;C07K14/475;C12N5/10;C12N15/01;C12N15/12;C12N15/63 |
主分类号 |
C12N1/13 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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