发明名称 |
Vectors/DNA-Sequences from Human Combinatorial Antibody Libraries |
摘要 |
The present invention relates to synthetic DNA sequences which encode one or more collections of homologous proteins/(poly)peptides, and methods for generating and applying libraries of these DNA sequences. In particular, the invention relates to the preparation of a library of human-derived antibody genes by the use of synthetic consensus sequences which cover the structural repertoire of antibodies encoded in the human genome. Furthermore, the invention relates to the use of a single consensus antibody gene as a universal framework for highly diverse antibody libraries. |
申请公布号 |
EP2058400(A1) |
申请公布日期 |
2009.05.13 |
申请号 |
EP20080006358 |
申请日期 |
1996.08.19 |
申请人 |
MORPHOSYS IP GMBH |
发明人 |
KNAPPIK, ACHIM;PACK, PETER;GE, LIMING |
分类号 |
C12N15/73;C07K1/04;C07K16/00;C12N1/21;C12N15/10;C12N15/13;C12N15/62;C12N15/63;C12N15/70 |
主分类号 |
C12N15/73 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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