| 发明名称 |
Chimeric relaxin polypeptides comprising an A and B chain derived from different relaxin family peptides |
| 摘要 |
<p>Provided herein are modified relaxin polypeptides wherein the B chain comprises the core amino acid sequence CGR-XXX-R-XX-I/V-XX-CG (SEQ ID NO:1), where X is any amino acid. Also provided are modified relaxin polypeptides comprising at least an A and a B chain, wherein the A and B chains are derived from different naturally occurring relaxins and wherein the B chain comprises the core amino acid sequence CGR-XXX-R-XX-I/V-XX-CG (SEQ ID NO:1), where X is any amino acid.</p> |
| 申请公布号 |
AU2008318278(A1) |
申请公布日期 |
2009.05.07 |
| 申请号 |
AU20080318278 |
申请日期 |
2008.10.30 |
| 申请人 |
HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE |
发明人 |
JOHN DESMOND WADE;CHRISHAN SURENDRAN SAMUEL;ROSS ALEXANDER DAVID BATHGATE;GEOFFREY W. TREGEAR;MOHAMMED AKHTER HOSSAIN |
| 分类号 |
C07K14/64;A61K31/13;A61K38/22;A61K38/28;A61K38/30;A61P9/00;A61P25/00;C07K14/575;C07K14/62;C07K14/65;C07K19/00;C12N15/16;C12N15/17;C12N15/18 |
主分类号 |
C07K14/64 |
| 代理机构 |
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